Location：
Home >
EneSoothe® Mix-Mankuka
  • EneSoothe® Mix-Mankuka
    • 1/1
  • EneSoothe® Mix-Mankuka

EneSoothe® Mix-Mankuka

INCI Name Nelumbo Nucifera Flower Water, Leptospermum Scoparium Leaf Extract, Stephania Tetrandra Extract, Butylene Glycol
Application Soothing and Anti-inflammation, Anti acne
Recommended use level 0.5~5.0%
Product Overview

EneSoothe® Mix-Mankuka is a fast-acting, water-free botanical complex derived from Lotus, Manuka, and Tetrandra. Inspired by traditional botanical wisdom and validated through modern science, it delivers powerful neuro-calming and multi-pathway anti-inflammatory benefits while helping regulate the key biological processes involved in blemish-prone skin.

It rapidly reduces visible redness, relieves burning and stinging sensations, helps regulate excess sebum, minimizes follicular hyperkeratinization, and supports skin barrier recovery. Ideal for formulations designed for sensitive, irritated and acne-prone skin.

Plant Source

This complex combines three traditionally valued botanicals to support skin comfort and balance.

Lotus provides hydration and skin-repair benefits and is applied as a functional hydrosol solvent in a water-free formulation.
Manuka, historically used by the Māori of New Zealand, delivers terpene-rich calming activity to soothe stressed skin.
Tetrandra contributes bioactive alkaloids known to help regulate key inflammatory pathways.

Key Benefits

• Instant visible redness relief

• Fast neuro-calming action to relieve burning and stinging sensations

• Helps regulate excess sebum

• Helps reduce follicular hyperkeratinization to support clearer skin

• Multi-pathway inflammation control

• Supports barrier recovery and improves skin resilience

Efficacy Data

In vitro

In vivo


  • Neuro-Soothing & Redness Control: Inhibits TRPV1 activation (-41.39%) and CaN–NFAT signaling (-71.9%) to reduce burning and stinging sensations


  • Sebum Regulation & Follicular Keratinization Control

    Helps regulate excess sebum production (-76.73%) and downregulates K16 (-23%) and K17 (-31%) expression, helping reduce follicular hyperkeratinization and support clearer-looking skin.


  • Multi-Pathway Inflammation Control

    COX-2 (-93.24%), 5-LOX (-65.57%), nitric oxide (NO, -19.3%), TNF-α (-16%) and IL-6 (-55%), helping reduce skin inflammation and discomfort.




  • Rapid Redness Relief: Reduces histamine-induced erythema by up to -97.6% within 90 minutes


  • Instant Soothing Effect: Visible redness reduction of -42% in 15 minutes under irritation conditions


  • Barrier Recovery: Decreases TEWL by -55.6% in 15 minutes, supporting rapid barrier restoration


  • Sun-Induced Damage Protection: Significantly reduces UV-induced redness and limits barrier disruption after sun exposure