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EneSoothe® Anti-itching Complex
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  • EneSoothe® Anti-itching Complex

EneSoothe® Anti-itching Complex

INCI Name Gentiana Macrophylla Extract, Swertia Bimaculata Extract, Gentiana Scabra Extract, Butylene Glycol, Water
Application Soothing and Anti-inflammation, Scalp Care
Recommended use level 0.5~10%
Product Overview

EneSoothe® Anti-itching Complex is a Gentiana-derived botanical complex designed to rapidly relieve itching while addressing the underlying causes of skin discomfort. Inspired by traditional herbal knowledge and supported by modern biological research, it targets neurogenic itch, inflammatory responses, and barrier impairment through multiple biological pathways.

By modulating key itch mediators including TRPV1, Substance P, histamine receptors, PAR2, and inflammatory cytokines, it helps interrupt the itch–inflammation–barrier damage cycle, providing immediate soothing while supporting long-lasting skin comfort and resilience.

Ideal for sensitive, irritated, eczema-prone, scalp care and post-procedure formulations. COSMOS APPROVAL.

Plant Source
Gentiana scabra

Native to mountainous regions exposed to strong UV radiation and harsh environmental conditions, Gentiana scabra naturally accumulates protective phytochemicals. Traditionally recognized as a cooling botanical, it has long been used to soothe redness, swelling and skin discomfort.

Swertia bimaculata

Growing in mountains, wetlands and forests, Swertia bimaculata develops rich bioactive compounds that help it adapt to environmental stress. Traditionally used to calm inflammatory conditions and restore balance.

Gentiana macrophylla

A classical medicinal herb with more than two thousand years of traditional use. Historically valued for relieving discomfort and inflammation, it contributes soothing and protective benefits for sensitive skin.

Key Benefits

• Rapidly relieves itching and skin discomfort

• Supports skin barrier recovery and resilience

• Helps reduce redness and irritation

• Provides immediate soothing with long-lasting comfort

• Suitable for facial, body and scalp care applications

Applications

• Anti-itch skincare • Sensitive skin care • Barrier repair products • Scalp soothing treatments • Baby & children's soothing care • Insect bite relief products

Efficacy Data

In vitro

In vivo

  • Promotes β-Endorphin expression for natural soothing

  • Inhibits TRPV1, reducing itch signal transmission

  • Suppresses NO production associated with Substance P signaling

  • Inhibits COX-2 activity by up to 73.6%

  • Inhibits 5-LOX activity by up to 39.6%



RNA sequencing

  • Downregulate histamine receptor signaling (HRH1/HRH4)

  • Suppress PAR2-mediated itch pathways

  • Reduce inflammatory cytokine signaling

  • Enhance barrier-related genes including FLG, TGM1, and CLDN5

  • Support epidermal regeneration and barrier resilience


Chronic Skin Itching

  • 85.7% experienced immediate itch relief

  • 71.4% maintained relief for 2–4 hours

  • 50% showed improved itching after 7 days

  • No reported adverse reactions


Barrier-Damaged & Sensitive Skin

  • 91.3% experienced immediate itch relief

  • 85.4% maintained relief for 2–4 hours

  • 70% showed improved itching after continuous use

  • Well tolerated with no reported adverse reactions


Scalp Itching (Leave-on)

  • 87.5% experienced immediate scalp itch relief

  • 95.8% maintained relief for 2–4 hours

  • 70% showed improved scalp itching

  • No significant discomfort reported


Scalp Itching & Redness (Rinse-off)

  • 188.9% reduction (a* value) in scalp redness after one use

  • 202.3% reduction (a* value) in scalp redness after 14 days

  • Rapid soothing from 15 seconds after washing

  • Lasting itch relief for up to 12 hours

  • Gentle for sensitive scalp